ZA80902B - N-substituted aziridine-2-carboxylic acid derivatives - Google Patents

N-substituted aziridine-2-carboxylic acid derivatives

Info

Publication number
ZA80902B
ZA80902B ZA00800902A ZA80902A ZA80902B ZA 80902 B ZA80902 B ZA 80902B ZA 00800902 A ZA00800902 A ZA 00800902A ZA 80902 A ZA80902 A ZA 80902A ZA 80902 B ZA80902 B ZA 80902B
Authority
ZA
South Africa
Prior art keywords
carboxylic acid
acid derivatives
substituted aziridine
aziridine
substituted
Prior art date
Application number
ZA00800902A
Other languages
English (en)
Inventor
U Bicker
W Kampe
E Bosies
M Thiel
D Boerner
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of ZA80902B publication Critical patent/ZA80902B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/22—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
ZA00800902A 1979-02-21 1980-02-18 N-substituted aziridine-2-carboxylic acid derivatives ZA80902B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792906603 DE2906603A1 (de) 1979-02-21 1979-02-21 N-substituierte aziridin-2-carbonsaeurederivate, verfahren zu deren herstellung sowie diese substanzen enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
ZA80902B true ZA80902B (en) 1981-03-25

Family

ID=6063481

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00800902A ZA80902B (en) 1979-02-21 1980-02-18 N-substituted aziridine-2-carboxylic acid derivatives

Country Status (19)

Country Link
US (2) US4397848A (en])
EP (1) EP0014976B1 (en])
JP (1) JPS55113760A (en])
AR (1) AR223863A1 (en])
AT (1) ATE818T1 (en])
AU (1) AU529982B2 (en])
CA (1) CA1148962A (en])
CS (1) CS208798B2 (en])
DD (1) DD148772A5 (en])
DE (2) DE2906603A1 (en])
ES (1) ES488656A1 (en])
FI (1) FI70702C (en])
HU (1) HU182801B (en])
IE (1) IE49267B1 (en])
IL (1) IL59425A (en])
PL (1) PL129707B1 (en])
PT (1) PT70847A (en])
SU (1) SU1181541A3 (en])
ZA (1) ZA80902B (en])

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925835A (en) * 1986-05-01 1990-05-15 Sloan-Kettering Institute For Cancer Research Aziridinyl putrescine containing compositions and their uses in treating prostate cancer
JPH07301287A (ja) * 1995-03-23 1995-11-14 Sumitomo Heavy Ind Ltd 制御装置に用いられる内接噛合遊星歯車機構
ES2210774T3 (es) * 1997-06-27 2004-07-01 Amplimed, Inc. Nuevas cianoaziridinas para el tratamiento del cancer.
US20030129222A1 (en) * 2000-11-21 2003-07-10 Gabriel Lopez-Berestein Liposomal imexon
CA2431947A1 (en) * 2000-11-21 2002-05-30 Gabriel Lopez-Berestein Composition comprising an imexon or derivatives thereof and lipids
WO2003055468A1 (en) * 2001-12-21 2003-07-10 Shire Laboratories Inc. Oral capsule formulation with increased physical stability
US20040005339A1 (en) * 2002-06-28 2004-01-08 Shojaei Amir H. Formulations of fenofibrate and/or fenofibrate derivatives with improved oral bioavailability
PL377847A1 (pl) 2003-01-14 2006-02-20 Arena Pharmaceuticals Inc. 1,2,3-Tripodstawione pochodne arylowe i heteroarylowe jako modulatory metabolizmu oraz profilaktyka i leczenie związanych z nim zaburzeń takich jak cukrzyca i hiperglikemia
CA2515963A1 (en) * 2003-02-24 2004-09-10 Arena Pharmaceuticals, Inc. Phenyl- and pyridylpiperidine-derivatives as modulators of glucose metabolism
AR045047A1 (es) 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
ATE415397T1 (de) * 2004-06-04 2008-12-15 Arena Pharm Inc Substituierte aryl- und heteroarylderivate als modulatoren des stoffwechsels und für die prophylaxe und behandlung von damit in zusammenhang stehenden erkrankungen
MY148521A (en) 2005-01-10 2013-04-30 Arena Pharm Inc Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
DOP2006000010A (es) 2005-01-10 2006-07-31 Arena Pharm Inc Procedimiento para preparar eteres aromáticos
GEP20104966B (en) * 2005-09-16 2010-04-26 Arena Pharm Inc Modulators of metabolism and the treatment of disorders related thereto
TW200811140A (en) * 2006-07-06 2008-03-01 Arena Pharm Inc Modulators of metabolism and the treatment of disorders related thereto
TW200811147A (en) * 2006-07-06 2008-03-01 Arena Pharm Inc Modulators of metabolism and the treatment of disorders related thereto
CN103221391B (zh) 2010-01-27 2018-07-06 艾尼纳制药公司 (R)-2-(7-(4-环戊基-3-(三氟甲基)苄基氧基)-1,2,3,4-四氢环戊二烯并[b]吲哚-3-基)乙酸及其盐的制备方法
PE20131371A1 (es) 2010-09-22 2013-11-25 Arena Pharm Inc Moduladores del receptor gpr119 y el tratamiento de trastornos relacionados con este
PT3242666T (pt) 2015-01-06 2024-12-09 Arena Pharm Inc Composto para utilização no tratamento de patologias relacionadas com o recetor s1p1
SI3310760T1 (sl) 2015-06-22 2023-02-28 Arena Pharmaceuticals, Inc. Kristalinična L-argininska sol (R)-2-(7-(4-ciklopentil-3-(trifluorometil)benziloksi)-1,2,3,4- tetrahidrociklo-penta(b)indol-3-il)ocetne kisline za uporabo pri motnjah, povezanih z receptorjem S1P1
WO2018151873A1 (en) 2017-02-16 2018-08-23 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
CA3102136A1 (en) 2018-06-06 2019-12-12 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the s1p1 receptor
CN113816887A (zh) * 2021-08-31 2021-12-21 华中科技大学 一种氮杂环丙烷类化合物及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2644820A1 (de) * 1976-10-05 1978-04-06 Boehringer Mannheim Gmbh Cancerostatisch und immunstimulierend wirkende 1-(n-acyl-carbamoyl)-2-cyanaziridine sowie verfahren zur herstellung derselben
DE2731264A1 (de) 1977-07-11 1979-02-01 Boehringer Mannheim Gmbh Neue 1-acyl-2-cyanaziridine, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische zubereitungen

Also Published As

Publication number Publication date
PL222088A1 (en]) 1980-12-01
FI800510A7 (fi) 1980-08-22
DE3060268D1 (en) 1982-05-19
ATE818T1 (de) 1982-04-15
FI70702B (fi) 1986-06-26
IL59425A (en) 1984-05-31
US4517183A (en) 1985-05-14
PL129707B1 (en) 1984-06-30
IE800327L (en) 1980-08-21
JPH0150700B2 (en]) 1989-10-31
IL59425A0 (en) 1980-05-30
DE2906603A1 (de) 1980-09-04
CA1148962A (en) 1983-06-28
AU529982B2 (en) 1983-06-30
EP0014976A1 (de) 1980-09-03
HU182801B (en) 1984-03-28
AU5564980A (en) 1980-08-28
FI70702C (fi) 1986-10-06
US4397848A (en) 1983-08-09
CS208798B2 (en) 1981-09-15
PT70847A (de) 1980-03-01
ES488656A1 (es) 1980-09-16
IE49267B1 (en) 1985-09-04
JPS55113760A (en) 1980-09-02
EP0014976B1 (de) 1982-04-07
AR223863A1 (es) 1981-09-30
SU1181541A3 (ru) 1985-09-23
DD148772A5 (de) 1981-06-10

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